| Home | Score | Away | League | Time (CST) |
|---|---|---|---|---|
| Deportes Quindío | 0:0 | Deportes Tolima | Copa Colombia | 07:15 |
| Ponte Preta | 1:0 | Athletic Club-MG | Brazilian Serie B | 06:30 |
| Juventude | 0:0 | Avaí | Brazilian Serie B | 06:30 |
| Independiente de Campo Grande | 0:0 | Deportivo Capiatá | Paraguayan División Intermedia | 06:30 |
| Banfield | 3:2 | Sarmiento | Argentinian Primera Division | 06:00 |
| Tigre | 1:2 | Nacional Montevideo | Copa Sudamericana | 06:00 |
| San Lorenzo | 1:0 | Gimnasia y Esgrima de Mendoza | Argentinian Primera Division | 06:00 |
| Cacahuatique | 4:2 | Atlético Balboa | El Salvador Primera Division | 05:30 |